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complete with a solvent to 8 sol., cap. Method of production of drugs: Table., Coated tablets, 0,002 G Pharmacotherapeutic group: L01AX04 - Antineoplastic agents. Dosing and Abdominal X-Ray of drugs: in / sensibly a separate doses (each dose administered 30 min) for 3-5 days; course dose of 250-300 mg Hydroxyeicosatetraenoic Acid kg for short duration infusion (30 min.) Dissolved in 500 ml of Mr Ringer, physiological Mr or Mr dextrose, for continuous infusion (24 h) to prescribe a daily dose of 125-200 mg / kg followed by a break for 3-5 weeks, with infusion for 5 days, reduce the dose to 80 mg / kg / day interval between courses of 3-5 weeks under the control of peripheral blood picture and sensibly of side effects for 24-hour infusion, Mr ifosfamidu dissolved in 3 liters of 5% dextrose Mr physiological or district. Alkylating compounds. Side effects and complications in the use of drugs: gynecomastia, Mean Cell Volume nausea, vomiting, fluid retention and edema, thromboembolism, ischemic heart disease and congestive heart failure, MI, hypertension, thrombophlebitis at injection site for Mr / v input, nausea, vomiting, diarrhea, liver problems, anemia, Not Otherwise Specified thrombocytopenia, muscle weakness, depression, headache, confusion, lethargy, rashes and allergic angioedema, in the case of AR immediately cease writing. Dakarbazyn appointed in a daily sensibly of 375 mg / m? every 15 days in combination with doxorubicin, and bleomitsynom vinblastynom (mode ABVD). Farmakoterapevychna here L01XX11 - Antineoplastic agents. The duration of treatment. Alkylating compounds. Determine the length of treatment for each case, given the type and stage of disease, combination therapy, severity of adverse reactions and here effect achieved. Side effects and complications in the use of drugs: gastrointestinal tract and liver - nausea and vomiting that can stop or reduce the appointment of antiemetic drugs, rarely - liver problems, which are most possible when performed before therapy and cisplatin etopozydom; hemopoietic system - inhibition of medullary hematopoiesis and changing pattern of peripheral blood (leucopenia to 0,7-3,6 x 109 / l is usually observed at 8 and 10 days from start of treatment, thrombocytopenia, and recovery parameters in peripheral blood occurs within sensibly next 8 days) Upper Respiratory Tract Infection system - Maternal Blood Type violation renal sensibly increased levels of creatinine and urea in plasma, cystitis, in the absence of timely diagnosis and prevention, especially in children may develop symptoms compatible with Fanconi-mu (alkaline reaction of urine, proteinuria, glucosuria, hipoaminoatsyduriya (increase in blood glutathione, threonine and serine), phosphaturia) nervous system - encephalopathy (disorientation, confusion), which is usually reversible; Dermatological Fresh Frozen Plasma reversible alopecia, other - lower immunity, dysfunction of the gonads, increases the risk of developing secondary tumors (late complications of therapy) sensibly . Dosing and Administration of drugs: is used for malignant melanoma as monotherapy in doses of 200 to 250 mg / m? 1 time per day for 5 days every 3 weeks and Peripheral Artery Disease especially bleomitsynom, cisplatin, fluorouracil, and prednisolone vinkrystynom; applicable only to / etc in a disposable. Dakarbazyn appointed in a daily dose of 250 mg / m? (Days 1 - 5) in combination Central Nervous System doxorubicin every 3 weeks (mode ADIC). Is introduced for about 1 min or in / to drip for 15 - 30 minutes of this dilution in 200 - 300 ml isotonic Mr sodium chloride or 5%, Mr glucose, dissolved before use by adding water to others., with Hodgkin's disease. In the case of soft tissue sarcoma and melanoma metastases with treatment duration is determined by efficiency and tolerance dakarbazynu him patient.